Compile Data Set for Download or QSAR
Report error Found 142 Enz. Inhib. hit(s) with all data for entry = 12940
Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743171(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 0.400nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743171(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 0.800nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743194((2S)-1-(7-(2- Amino-3-cyano- 7- fluorobenzo[b] thi...)
Affinity DataIC50: 1nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743199(2-Amino-4-(6- chloro-8-fluoro- 4-(6-fluoro-1,4- ox...)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743142(US20250163064, Example 1)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743142(US20250163064, Example 1)
Affinity DataIC50: 1nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743172(2-Amino-4-(4- (azocan-1-yl)-6- chloro-8-fluoro- 2-...)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743172(2-Amino-4-(4- (azocan-1-yl)-6- chloro-8-fluoro- 2-...)
Affinity DataIC50: 1nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743203(US20250163064, Example 62)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743194((2S)-1-(7-(2- Amino-3-cyano- 7- fluorobenzo[b] thi...)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743192(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743192(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743159(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743159(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743165(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743149(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743163(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743163(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743185(2-Amino-4-(6- chloro-4-(6- ethyl-6-hydroxy- 1,4-ox...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743168(2-Amino-4-(6- chloro-8-fluoro- 4-(3- fluoroazepan-...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743200(2-Amino-4-(6- chloro-8-fluoro- 4-(6-fluoro-1,4- ox...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743168(2-Amino-4-(6- chloro-8-fluoro- 4-(3- fluoroazepan-...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743173(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743157(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7a.S)-2- fl...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743173(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743146(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7a.S)-2- fl...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743174(4-(4-(6-Oxa-3- azabicyclo[3.2.1] octan-3-yl)-6- ch...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743166(2-Amino-4-(6- chloro-4-(1,1- dioxido-1,4- thiazepa...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743182(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743198(1-(7-(2-Amino-3- cyano-7- fluorobenzo[b] thiophen-...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743165(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743185(2-Amino-4-(6- chloro-4-(6- ethyl-6-hydroxy- 1,4-ox...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743169(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743199(2-Amino-4-(6- chloro-8-fluoro- 4-(6-fluoro-1,4- ox...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743166(2-Amino-4-(6- chloro-4-(1,1- dioxido-1,4- thiazepa...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743198(1-(7-(2-Amino-3- cyano-7- fluorobenzo[b] thiophen-...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743158(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743174(4-(4-(6-Oxa-3- azabicyclo[3.2.1] octan-3-yl)-6- ch...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743157(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7a.S)-2- fl...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743204(US20250163064, Example 63)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743156(1-(7-(2-Amino-3- cyano-7- fluorobenzo[b] thiophen-...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743187(2-Amino-4-(6- chloro-4-(6- (difluoromethyl)- 6-hyd...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743203(US20250163064, Example 62)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743202(US20250163064, Example 61)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743145(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743176(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743144(1-(7-(2-Amino-3- cyano-7- fluorobenzo[b] thiophen-...)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743175(2-Amino-4-(6- chloro-4-(6,6- difluoro-1,4- oxazepa...)
Affinity DataIC50: 4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743175(2-Amino-4-(6- chloro-4-(6,6- difluoro-1,4- oxazepa...)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743190(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

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