Compile Data Set for Download or QSAR
Report error Found 101 Enz. Inhib. hit(s) with all data for entry = 12978
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747216BDBM747216((S)-2-amino-1-(6,7-dichloro-1-methyl-1,3,4,5-tetra...)
Affinity DataIC50: 17.8nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747258BDBM747258((S)-1-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H...)
Affinity DataIC50: 19nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747254BDBM747254((S)-1-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H...)
Affinity DataIC50: 19nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747260BDBM747260(WO-2020/186027, Compound 67 | 1-(7,8-dichloro-10-(...)
Affinity DataIC50: 27.3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 32nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747252BDBM747252((S)-2-amino-1-(7,8-dichloro-1-methyl-3,4-dihydropy...)
Affinity DataIC50: 33.1nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747262BDBM747262((S)-2-amino-1-(7,8-dichloro-1-methyl-3,4- dihydrop...)
Affinity DataIC50: 33.1nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 50582657BDBM50582657(CHEMBL5082056 | US20250179079, Comparative Example...)
Affinity DataIC50: 35.2nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747208BDBM747208((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 37.4nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747214BDBM747214(2-amino-1-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydr...)
Affinity DataIC50: 37.7nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747253BDBM747253((6,7-dichloro-9-methoxy-1-methyl-1,3,4,5-tetrahydr...)
Affinity DataIC50: 45.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747210BDBM747210((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 50.1nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747209BDBM747209((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 51.4nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747211BDBM747211((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 52nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747229BDBM747229((S)-1-(7,8-dichloro-1-methyl-10-(1-methyl-1H-pyraz...)
Affinity DataIC50: 59.9nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747205BDBM747205((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 68.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747206BDBM747206((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 69.2nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747218BDBM747218((S)-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1,2...)
Affinity DataIC50: 71.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747236BDBM747236((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 78.7nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747261BDBM747261((S)-1-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1...)
Affinity DataIC50: 82.8nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747227BDBM747227((S)-1-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1...)
Affinity DataIC50: 82.8nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747213BDBM747213((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 89.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747242BDBM747242((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 90.4nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747234BDBM747234((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 94.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747255BDBM747255(2-amino-1-(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyri...)
Affinity DataIC50: 95nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747212BDBM747212((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 102nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747244BDBM747244((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 110nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747250BDBM747250((6,7-dichloro-1,9-dimethyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 115nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747237BDBM747237((6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5...)
Affinity DataIC50: 133nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747256BDBM747256(WO-2019/153002, TDI-005685 | 1-(6,7-dichloro-1,3,4...)
Affinity DataIC50: 146nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747193BDBM747193((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 156nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747238BDBM747238((6,7-dichloro-9-(pyrimidin-5-yl)-1,3,4,5-tetrahydr...)
Affinity DataIC50: 156nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747190BDBM747190((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 174nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747194BDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 177nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747196BDBM747196((R)-(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3...)
Affinity DataIC50: 188nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747243BDBM747243((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 206nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747199BDBM747199((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 207nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747201BDBM747201((R)-(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3...)
Affinity DataIC50: 209nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747195BDBM747195((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 219nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747192BDBM747192((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 222nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747239BDBM747239((6,7-dichloro-9-(pyridin-3-yl)-1,3,4,5-tetrahydro-...)
Affinity DataIC50: 224nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 226nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747197BDBM747197((S)-(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3...)
Affinity DataIC50: 236nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747198BDBM747198((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 245nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747233BDBM747233((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 251nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747203BDBM747203((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 256nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747200BDBM747200((S)-(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3...)
Affinity DataIC50: 259nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747202BDBM747202((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 297nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747232BDBM747232(2-amino-1-(8,9-dichloro-1,2,4,5,6,7-hexahydro-1,5-...)
Affinity DataIC50: 314nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747204BDBM747204((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 337nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

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