Compile Data Set for Download or QSAR
Report error Found 283 Enz. Inhib. hit(s) with all data for entry = 13240
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770046BDBM770046(N-(4-(4-((1-methyl-1H- pyrazol-5- yl)methyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770047BDBM770047(N-(4-(4-(2,2- dimethylcyclopropane-1- carbonyl)pip...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770048BDBM770048(N-(4-(4-(2-methoxy-2- methylpropyl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770049BDBM770049(N-(3-amino-4-(4- cyclopentylpiperazin-1- yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770050BDBM770050(N-(4-(4-(2- cyclopropylacetyl)piperazin- 1-yl)phen...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770052BDBM770052(N-(4-(4- (cyclobutanecarbonyl) piperazin- 1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770053BDBM770053(N-(4-(4-isobutyrylpiperazin- 1-yl)phenyl)-4-((8-me...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770055BDBM770055(N-(4-(4-(3,3- dimethylazetidine-1- carbonyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770056BDBM770056(N-(4-(4-(3,3- difluorocyclobutane-1- carbonyl)pipe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770057BDBM770057(N-(4-(4-(3,3- difluoroazetidine-1- carbonyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770058BDBM770058(N-(4-(4-(2- azaspiro[3.3]heptane-2- carbonyl)piper...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770031BDBM770031(N-(4-(4-(2- methoxyethyl)piperazin-1-yl)- 3-methyl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770032BDBM770032(N-(3-amino-4-(4- methylpiperazin-1-yl)phenyl)- 4-(...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770036BDBM770036(N-(4-(4-(2-(dimethylamino)- 2-oxoethyl)piperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770038BDBM770038(N-(4-(4-(2-hydroxypropan-2- yl)piperidin-1-yl)phen...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770040BDBM770040(N-(4-(4-(1- hydroxyethyl)piperidin-1- yl)phenyl)-4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770041BDBM770041(N-(4-(4-(1H-pyrazole-5- carbonyl)piperazin-1- yl)p...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770042BDBM770042(N-(4-(4-(3,3- dimethylcyclobutane-1- carbonyl)pipe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770043BDBM770043(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770044BDBM770044(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770045BDBM770045(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770078BDBM770078(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770079BDBM770079(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770080BDBM770080(N-(4-(4-(2-fluoro-2- methylpropanoyl)piperazin-1- ...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770081BDBM770081((S)-N-(4-(4-isobutyryl-3- methylpiperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770082BDBM770082(N-(4-(4-(2-methoxy-2- methylpropanoyl)piperazin-1-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770083BDBM770083((S)-4-((8-methyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770084BDBM770084((S)-N-(4-(4-(2- methoxyethyl)-3- methylpiperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770085BDBM770085((R)-4-((8-methyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770086BDBM770086((R)-N-(4-(4-(2- methoxyethyl)-3- methylpiperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770087BDBM770087((R)-N-(4-(4-isobutyryl-3- methylpiperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770088BDBM770088((S)-N-(4-(4-(2- methoxypropanoyl)piperazin- 1-yl)p...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770093BDBM770093(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770062BDBM770062(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769880BDBM769880(N-(4-(4-hydroxypiperidin-1- yl)phenyl)-4-((8-methy...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770063BDBM770063(N-(4-(4-(azetidine-1- carbonyl)piperazin-1- yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770064BDBM770064(4-((3,8-dimethyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769878BDBM769878(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770065BDBM770065((S)-N-(4- (hexahydropyrazino[2,1- c][1,4]oxazin-8(...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769877BDBM769877(N-(4-(4-(2- hydroxypropyl)piperazin-1- yl)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770066BDBM770066((S)-N-(4- (hexahydropyrrolo[1,2- a]pyrazin-2(1H)-y...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769876BDBM769876(N-(4-(4-(3- methoxypropyl)piperazin-1- yl)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770067BDBM770067((R)-N-(4- (hexahydropyrrolo[1,2- a]pyrazin-2(1H)-y...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769850BDBM769850(4-((3,8-dimethyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770070BDBM770070(N-(4-(4- (cyclopropanecarbonyl) piperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769835BDBM769835(N-(3-fluoro-4-(1-(2- methoxyethyl)piperidin-4- yl)...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770071BDBM770071(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770072BDBM770072(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 769825BDBM769825(N-(3-methyl-1,2,3,4,4a,5- hexahydrobenzo[b]pyrazin...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 770074BDBM770074(N-(4-(4-(1-methyl-1H- pyrazol-3-yl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

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