Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 10890
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576396(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  31nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576414(7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4...)
Affinity DataKd:  39nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576397(7-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  14nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576397(7-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataKd:  17nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576398(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7- ethyl-1,3-ben...)
Affinity DataEC50:  20nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576398(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7- ethyl-1,3-ben...)
Affinity DataKd:  20nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576399(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro eth...)
Affinity DataEC50:  40nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576399(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro eth...)
Affinity DataKd:  49nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576400(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-1,3-benzothiazol...)
Affinity DataEC50:  52nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576400(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-1,3-benzothiazol...)
Affinity DataKd:  52nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576401(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-ben...)
Affinity DataEC50:  1.78E+3nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576401(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-ben...)
Affinity DataKd:  574nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576402(4-(1,3-benzothiazol-4-yl)-5-methyl-1 H-pyrazole-3-...)
Affinity DataEC50:  66nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576402(4-(1,3-benzothiazol-4-yl)-5-methyl-1 H-pyrazole-3-...)
Affinity DataKd:  74nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576403(5-methyl-4-(7-methyl-1,3-benzothiazol-4-yl)-1H-pyr...)
Affinity DataEC50:  20nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576403(5-methyl-4-(7-methyl-1,3-benzothiazol-4-yl)-1H-pyr...)
Affinity DataKd:  27nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576404(5-methyl-4-[7-(trifluoromethyl)-1,3-benzothiazol-4...)
Affinity DataEC50:  36nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576404(5-methyl-4-[7-(trifluoromethyl)-1,3-benzothiazol-4...)
Affinity DataKd:  620nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576405(4-(3,5-dimethyl-1H-pyrazol-4-yl)[1,3]thiazolo[4,5-...)
Affinity DataEC50:  894nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576405(4-(3,5-dimethyl-1H-pyrazol-4-yl)[1,3]thiazolo[4,5-...)
Affinity DataKd:  297nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576406(WO2022112919, Example 11)
Affinity DataEC50:  36nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576407(4-(3,5-di ethyl-1H-pyrazol-4-yl)-7-fluoro-1,3-benz...)
Affinity DataEC50:  37nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576408(4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-ben...)
Affinity DataEC50:  21nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576408(4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-ben...)
Affinity DataKd:  58nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576409(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-methoxy-1,3-ben...)
Affinity DataEC50:  25nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576409(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-methoxy-1,3-ben...)
Affinity DataKd:  31nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576410(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-fluoro-1,3-benz...)
Affinity DataEC50:  21nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576410(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-fluoro-1,3-benz...)
Affinity DataKd:  27nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576411(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  159nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576412(4-(3,5-dimethyl-1H-pyrazol-4-yl)-5-fluoro-1,3-benz...)
Affinity DataEC50:  29nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576413(4-[5- ethyl-3-(trifluoro ethyl)-1 H-pyrazol-4-yl]-...)
Affinity DataEC50:  133nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576414(7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4...)
Affinity DataEC50:  165nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576396(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataKd:  39nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed