Compile Data Set for Download or QSAR
maximum 50k data
Found 87 Enz. Inhib. hit(s) with all data for entry = 10913
LigandPNGBDBM577554(2-[[1-[(1 R)-2,2-Difluoro-1-methyl-ethyl]-3-(oxeta...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577560(7-[(3R,4R)-4-Methyltetrahydrofuran-3-yl]-2-[[1-(ox...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577560(7-[(3R,4R)-4-Methyltetrahydrofuran-3-yl]-2-[[1-(ox...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577575(2-((1-Methyl-3-(oxetan-3-yloxy)-1 H-pyrazol-4-yl)a...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577554(2-[[1-[(1 R)-2,2-Difluoro-1-methyl-ethyl]-3-(oxeta...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577571(2-((1-Methyl-3-(((R)-1 ,1 ,1-trifluoropropan-2-yl)...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577571(2-((1-Methyl-3-(((R)-1 ,1 ,1-trifluoropropan-2-yl)...)
Affinity DataIC50:  1nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577564(2-[[1-(Methylsulfonylmethyl)-3-(oxetan-3-yloxy)pyr...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
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LigandPNGBDBM577564(2-[[1-(Methylsulfonylmethyl)-3-(oxetan-3-yloxy)pyr...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577557(2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577568(2-((3-(((S)-1-acetyl-2,2-dimethylazetidin-3-yl)oxy...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577568(2-((3-(((S)-1-acetyl-2,2-dimethylazetidin-3-yl)oxy...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577557(2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  2nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577570(2-((4-(2-Hydroxypropan-2-yl)-2-(oxetan-3-yloxy)phe...)
Affinity DataIC50:  3nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577570(2-((4-(2-Hydroxypropan-2-yl)-2-(oxetan-3-yloxy)phe...)
Affinity DataIC50:  3nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577567(2-((3-(((R)-1 -Acetyl-2, 2-dimethylazetidin-3-yl)o...)
Affinity DataIC50:  3nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
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LigandPNGBDBM577567(2-((3-(((R)-1 -Acetyl-2, 2-dimethylazetidin-3-yl)o...)
Affinity DataIC50:  3nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577556(2-((1-Methyl-3-(((2R,3S)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  3nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577556(2-((1-Methyl-3-(((2R,3S)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577556(2-((1-Methyl-3-(((2R,3S)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577553(2-[[1 -methyl-3-[(3S,4R)-4-methyltetrahydrofuran-3...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577555(2-[[1 -[(1 S)-2,2-difluoro-1 -methyl-ethyl]-3-(oxe...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577574(2-((1 -(methyl-d3)-3-(((2S,3S)-2-methyloxetan-3-yl...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM577587(2-((1-((S)-1-Cyanoethyl)-3-isopropoxy-1 H-pyrazol-...)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577558(WO2022263472, Example 19 | WO2022263472, Example 8)
Affinity DataIC50:  4nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577555(2-[[1 -[(1 S)-2,2-difluoro-1 -methyl-ethyl]-3-(oxe...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577553(2-[[1 -methyl-3-[(3S,4R)-4-methyltetrahydrofuran-3...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577559(2-[[1-[2-Hydroxy-1-methyl-ethyl]-3-(oxetan-3-yloxy...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577552(2-[[1-Methyl-3-[(3R,4S)-4-methyltetrahydrofuran-3-...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577552(2-[[1-Methyl-3-[(3R,4S)-4-methyltetrahydrofuran-3-...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577556(2-((1-Methyl-3-(((2R,3S)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577559(2-[[1-[2-Hydroxy-1-methyl-ethyl]-3-(oxetan-3-yloxy...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577558(WO2022263472, Example 19 | WO2022263472, Example 8)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577558(WO2022263472, Example 19 | WO2022263472, Example 8)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577582((R)-2-((1-Methyl-3-(oxetan-3-yloxy)-1 H-pyrazol-4-...)
Affinity DataIC50:  5nMAssay Description: LRRK2(human) is incubated with 50 mM HEPES pH 8.0, 0.2 mM EDTA, 0.01 %Brij-35, 1% (w/v) BSA, 5 mM DTT, 250 Mm RLGRDKYKTLRQIRQ, 10 mM Magnesium aceta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577551(2-[[3-(1-acetylazetidin-3-yl)oxy-1-methyl-pyrazol-...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577574(2-((1 -(methyl-d3)-3-(((2S,3S)-2-methyloxetan-3-yl...)
Affinity DataIC50:  5nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577562(2-[[3-[(3R,4R)-4-Methoxytetrahydrofuran-3-yl]oxy-1...)
Affinity DataIC50:  6nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577558(WO2022263472, Example 19 | WO2022263472, Example 8)
Affinity DataIC50:  6nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577551(2-[[3-(1-acetylazetidin-3-yl)oxy-1-methyl-pyrazol-...)
Affinity DataIC50:  6nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577599(WO2022263472, Example 80)
Affinity DataIC50:  6nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577557(2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  7nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577557(2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...)
Affinity DataIC50:  7nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577581(2-((1-((S)-1-cyanoethyl)-3-isopropoxy-1H-pyrazol-4...)
Affinity DataIC50:  7nMAssay Description: LRRK2(human) is incubated with 50 mM HEPES pH 8.0, 0.2 mM EDTA, 0.01 %Brij-35, 1% (w/v) BSA, 5 mM DTT, 250 Mm RLGRDKYKTLRQIRQ, 10 mM Magnesium aceta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577587(2-((1-((S)-1-Cyanoethyl)-3-isopropoxy-1 H-pyrazol-...)
Affinity DataIC50:  7nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM577573(2-((1-(Methyl-d3)-3-(((2R,3R)-2-methyloxetan-3-yl)...)
Affinity DataIC50:  8nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577562(2-[[3-[(3R,4R)-4-Methoxytetrahydrofuran-3-yl]oxy-1...)
Affinity DataIC50:  8nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM577563(2-[[3-[(3S,4S)-4-methoxytetrahydrofuran-3-yl]oxy-1...)
Affinity DataIC50:  9nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577599(WO2022263472, Example 80)
Affinity DataIC50:  9nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Sanofi

WIPO
LigandPNGBDBM577573(2-((1-(Methyl-d3)-3-(((2R,3R)-2-methyloxetan-3-yl)...)
Affinity DataIC50:  10nMAssay Description:The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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