| Solution Information | help | |
| Enzyme: | Transthyretin | |
| inhibitor: | BDBM128206 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine dose responses curves for compounds identified as active in a set of previous experiments entitled, "Luminescence-based cell-based primary high throughput screening assay to identify activators of Transthyretin (TTR) transcription" (PubChem AID 1117267) and "Luminescence-based cell-based high throughput confirmation assay to identify activators of Transthyretin (TTR) transcription" (PubChem AID 1117280) and active in a set of experiments entitled, "Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells" (PubChem AID 1117279). In this assay, SHSY5Y human neuroblastoma cells stably expressing the Gaussia luciferase (eGLuc2) gene under the control of 2kb of the human TTR promoter (SHSY5Y TTR eGLuc2) are incubated with test compounds for a defined period, followed by the addition of luc | |
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