Reaction Details  Report a problem with these data
Cell Reactant:
Cyclin-dependent protein kinase 2 (CDK2 WT)
Syringe Reactant:
BDBM154576
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/15/15
ΔG°:
-40±0 (kJ/mole)
pH:
7.5±0
Temperature:
288.15±0 (K)
ΔH° :
-61.9±n/a (kJ/mole)
ΔHobs :
-62.4±0 (kJ/mole)
ΔS° :
-0.076±0 (kJ/mole-K)
Citation
 Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article 
Cell React
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Syringe React
Name:
BDBM154576
Synonyms:
K03861 (1)
Type:
Small organic molecule
Emp. Form.:
C24H26F3N7O2
Mol. Mass.:
501.5041
SMILES:
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Structure:
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