Reaction Details  Report a problem with these data
Cell Reactant:
Phosphoehtnaolamine Methyltransferases 1 (PMT1)
Syringe Reactant:
BDBM28422
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
09/18/12
ΔG°:
-6.94±0.24 (kcal/mole)
pH:
7.5±0
Temperature:
277.15±0 (K)
ΔH° :
-12.73±0.19 (kJ/mole)
ΔS° :
-0.02±0 (kJ/mole-K)
Citation
 Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286:38060-8 (2011) [PubMed]  Article 
Cell React
Name:
Phosphoethanolamine N-methyltransferase 1
Synonyms:
Phosphoehtnaolamine Methyltransferases 1 (PMT1)
Type:
Enzyme
Mol. Mass.:
53531.36
Organism:
Caenorhabditis elegans
Description:
Q86NB3
Residue:
475
Sequence:
MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILASLPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDAVGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKAKSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQVHWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLPSNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFGWNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNEAEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH
  
Syringe React
Name:
BDBM28422
Synonyms:
(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfanylium)butanoate | AdoMet | S-Adenosylmethionine | S-adenosyl-L-[carboxy-14C]methionine | [14COOH]AdoMet
Type:
radiolabeled substrate
Emp. Form.:
C15H22N6O5S
Mol. Mass.:
398.437
SMILES:
C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: