Reaction Details  Report a problem with these data
Cell Reactant:
Purine nucleoside phosphorylase
Syringe Reactant:
BDBM50293064
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2013-03-18
pH:
7.4000±0.0000
Temperature:
300.1500±0.0000 (K)
ΔH° :
-13.33±0.48 (kJ/mole)
Citation
 Edwards, AA; Mason, JM; Clinch, K; Tyler, PC; Evans, GB; Schramm, VL Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry 48:5226-38 (2009) [PubMed]  Article 
Cell React
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | Purine nucleoside phosphorylase (PNPase) | PNPH_HUMAN | PNP | NP
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Human
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Syringe React
Name:
BDBM50293064
Synonyms:
Immucillins, 10 | CHEMBL523107 | 7-({[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
Type:
Small organic molecule
Emp. Form.:
C11 H16 N4 O4
Mol. Mass.:
268.26913
SMILES:
OCC(CO)(CO)NCc1c[nH]c2c1nc[nH]c2=O
Structure:
Search PDB for entries with ligand similarity: