Reaction Details  Report a problem with these data
Cell Reactant:
MAP kinase ERK1
Syringe Reactant:
BDBM103302
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2014-10-22
ΔG°:
-8.79±n/a (kcal/mole)
pH:
7.5000±0.0000
Temperature:
288.1500±0.0000 (K)
ΔH° :
-20.62±0.19 (kJ/mole)
ΔS° :
-0.04±0 (kJ/mole-K)
Citation
 Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol 10:853-860 (2014) [PubMed]  Article 
Cell React
Name:
Mitogen-activated protein kinase 3
Synonyms:
MAP kinase ERK1 | Mitogen-activated protein kinase | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MK03_HUMAN | MAPK3 | ERK1 | PRKM3 | Mitogen-activated protein kinase 3 | MAPK3/MAPK7
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Human
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Syringe React
Name:
BDBM103302
Synonyms:
SCH772984 | US8546404, 6
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Structure:
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