Cell Reactant:
Lipoxygenase type I-B (LOX)
Syringe Reactant:
BDBM50148573
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/01/15
ΔG°:
-7.49±0 (kcal/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
-616.75±0 (kJ/mole)
ΔS° :
-2.04±0 (kJ/mole-K)
Citation
 Tomy, MJSharanya, CSDileep, KVPrasanth, SSabu, ASadasivan, CHaridas, M Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study. Chem Biol Drug Des 85:715-21 (2015) [PubMed]  Article
Cell React
Name:
Lipoxygenase type I-B (LOX)
Synonyms:
LOX1.2 | LOX2 | LOX2_SOYBN
Type:
Protein
Mol. Mass.:
97147.48
Organism:
Glycine max (Soybean)
Description:
n/a
Residue:
865
Sequence:
MFSVPGVSGILNRGGGHKIKGTVVLMRKNVLDFNSVADLTKGNVGGLIGTGLNVVGSTLDNLTAFLGRSVALQLISATKPLANGKGKVGKDTFLEGIIVSLPTLGAGESAFNIQFEWDESMGIPGAFYIKNYMQVEFYLKSLTLEDVPNQGTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAALVGYREEELKNLRGDGKGERKEHDRIYDYDVYNDLGNPDHGENFARPILGGSSTHPYPRRGRTGRYPTRKDQNSEKPGEVYVPRDENFGHLKSSDFLAYGIKSLSQYVLPAFESVFDLNFTPNEFDSFQDVRDLHEGGIKLPTEVISTIMPLPVVKELFRTDGEQVLKFPPPHVIQVSKSAWMTDEEFAREMVAGVNPCVIRGLQEFPPKSNLDPTIYGEQTSKITADALDLDGYTVDEALASRRLFMLDYHDVFMPYIRRINQTYAKAYATRTILFLRENGTLKPVAIELSLPHPAGDLSGAVSQVILPAKEGVESTIWLLAKAYVVVNDSCYHQLMSHWLNTHAVIEPFIIATNRHLSALHPIYKLLTPHYRDTMNINALARQSLINADGIIEKSFLPSKHSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSAPHGLRLLIEDYPYAVDGLEIWAAIKTWVQEYVSLYYARDDDVKPDSELQQWWKEAVEKGHGDLKDKPWWPKLQTIEELVEICTIIIWTASALHAAVNFGQYPYGGFILNRPTSSRRLLPEKGTPEYEEMVKSHQKAYLRTITSKFQTLVDLSVIEILSRHASDEVYLGQRDNPHWTSDSKALQAFQKFGNKLKEIEEKLARKNNDQSLSNRLGPVQLPYTLLHPNSEGLTCRGIPNSISI
  
Syringe React
Name:
BDBM50148573
Synonyms:
(E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine | 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine | 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine | 1-piperoylpiperidine | CHEMBL43185 | N-[(E,E)-piperoyl]piperidine | piperine
Type:
Small organic molecule
Emp. Form.:
C17H19NO3
Mol. Mass.:
285.3377
SMILES:
O=C(\C=C\C=C\c1ccc2OCOc2c1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: