Cell Reactant:
Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Syringe Reactant:
BDBM154576
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/15/15
ΔG°:
-42.7±0 (kJ/mole)
pH:
7.5±0
Temperature:
288.15±0 (K)
ΔH° :
-62.58±n/a (kJ/mole)
ΔHobs :
-62.8±0 (kJ/mole)
ΔS° :
-0.069±0 (kJ/mole-K)
Citation
 Alexander, LTM÷bitz, HDrueckes, PSavitsky, PFedorov, OElkins, JMDeane, CMCowan-Jacob, SWKnapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article 
Cell React
Name:
Cyclin-dependent kinase 2 [C118L]
Synonyms:
CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Type:
Protein
Mol. Mass.:
33948.19
Organism:
Homo sapiens (Human)
Description:
CDK2 mutant (C118L)
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Syringe React
Name:
BDBM154576
Synonyms:
K03861 (1)
Type:
Small organic molecule
Emp. Form.:
C24H26F3N7O2
Mol. Mass.:
501.5041
SMILES:
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Structure:
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