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Target
Lysyl oxidase homolog 2
Ligand
BDBM509206
Substrate
n/a
Meas. Tech.
Amine Oxidase Activity Assay
IC50
650±n/a nM
Citation
 Rowbottom, MW; Hutchinson, JH; Calderon, I Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof US Patent  US11072585 Publication Date 7/27/2021 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14
Type:
PROTEIN
Mol. Mass.:
86721.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115990
Residue:
774
Sequence:
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
  
Inhibitor
Name:
BDBM509206
Synonyms:
Compound 1-244 | US11072585, Example 101
Type:
Small organic molecule
Emp. Form.:
C16H20F3N3O2
Mol. Mass.:
343.3441
SMILES:
CC(=O)N1CCC2(CC(C2)Oc2cc(CN)cc(n2)C(F)(F)F)C1 |(7.46,-33.48,;8.37,-32.23,;9.9,-32.39,;7.74,-30.82,;8.51,-29.49,;7.48,-28.35,;6.07,-28.97,;4.59,-29.37,;4.19,-27.88,;5.68,-27.48,;2.85,-27.11,;2.85,-25.57,;4.19,-24.8,;4.19,-23.26,;5.52,-22.49,;6.86,-23.26,;2.85,-22.49,;1.52,-23.26,;1.52,-24.8,;.19,-22.49,;-1.15,-23.26,;.19,-20.95,;.19,-24.03,;6.24,-30.5,)|
Structure:
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