Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM520710
Substrate
n/a
Meas. Tech.
Calcium++ Mobilization Assay
IC50
5500±n/a nM
Citation
 Li, Y; Guo, R; Riedemann, NC Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor US Patent  US11149009 Publication Date 10/19/2021 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM520710
Synonyms:
US11149009, Compound INF075
Type:
Small organic molecule
Emp. Form.:
C33H31ClF7N3O2
Mol. Mass.:
670.06
SMILES:
Cc1ccc(NC(=O)[C@H]2C[C@H](CN([C@H]2c2ccc(NC3CCCC3)cc2)C(=O)c2c(F)cccc2Cl)C(F)(F)F)cc1C(F)(F)F |r|
Structure:
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