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Target
PI3K/PI4K catalytic domain-containing protein
Ligand
BDBM533837
Substrate
n/a
IC50
>1000±n/a nM
Citation
 Michael, YJ; Robert, TM; Peichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPO 0:0 (2022) [PubMed] 
Target
Name:
PI3K/PI4K catalytic domain-containing protein
Synonyms:
PI3K/PI4K domain-containing protein
Type:
Protein
Mol. Mass.:
252626.40
Organism:
n/a
Description:
A0A0S4TH36
Residue:
2159
Sequence:
MSCGNKYFWNLEGHDPALALLDLFENGKKYNSLETLVDFLSKNIVLLENMKNNSNSKKEGLFNFLFLFQKLNGRPAENENPEPVPLLSLDLKLADTILVQKALLRDLVFLLGNREFDVFRRLYSLLIKFAPLDLKDLISIEKNHGSMICIYFTIYFSILLNIFGYENIGEFRKGEEIEELKLNWINKFVSQINDLLDYFIDKKTNLLRITDINNDCLILIFALILYLIISIIDIGNDKITEFKLAIIKLIKIQLSNLMFNYWYLKILLIIIERIGMDLTVSELVLVVLQYQKFIGEQSIKIENNNSFDKSMNKLGVFETHIVTHLCRTWVVKEITLKKQLMEFVEQFIFTYGKLKEKKFDDYFLKKEDDLSMLDPINIVFIKLVSLFSKAFGVSMTGIDKEEYKNKEISDSKEIDSLVLLNLLEELLQGRRSQKICGLILFDSIRMLVTVLTILVDHRNFESENYDIKREIIQNDLVIVNLHKGGWNLKAYKCIDLIEKLFEIITHLIIRYKEDHKELNNSVNTISSVSSSSTGSIFKTTSFDISLFLIVWKNYVTLITRKEYRTDPIIFNKSIHLISLYLVSRKYKLDMLCEITFPISEYSDNLPILLDERYSDLIDLWTILWRNYLNENTNLFYNKRDEVENIFTVPNINYFFEYLRILDQVITQNNGISSPGLALSDKESMYTQKFTTKVLELTGIISSILICHKIVHSSDRHNTLMAILSASENPRIMSEYIYKQATNSLQFDGAYIYNCLKFFREKWSSSIKIRVFSLISDLYISIMKQSLFQFIQCLLSNFSVRGGIFEKSFALFKVRGMRGIISEEDFEVLQQKLTNIFSYSNSDLDGDLTSSLIKNEIFFGCYSIDLYYTINNIQKGWQSPSLSITPSSPKTFLNKKRHSSLMITDSEDVYSIINRLNPLFDQLINDDDYLKLFMDTVGEISKCYFYFLFENKSSDSGERSLIDQISNFSTIFGVKFEDEKFMASMNLKNELLKNVNYSNPTEEVIVERFNYKFYSQLIIRMIYLCTWMIVDNNYESYKSLSDLFAEKILNGLFGISNDEGGNHTSSYKFSQGNDQFDRFKSSLTDDYVLEHYTKFVCIIWSIISSMDPESIYKSYIKILERESLSYYQLYILLVFLIESSDWFIHHGYFQHINLLKILRQVELMTCLSSAYLQVKDENKEKTSQINSSDLHLKILLVCLIQKSITVEISKEVPLECYKKKHPTILKTNHNDLDIPQIRIYKFNNKSNQRDAYINGGRSMISTSYFLSCRILPYLWSFYESYPTYKDIYTRLLQSSTQLTTYLDNLCVNLYETKNWQKMMNNFNNVHLESSVEIYDNRLIPYNQYIVLEYIWEYFINGNTMILIEKYISALIFSIYSSKKVGFFEVWLLLSLWKRYPARIYRHMMKTSSTWIVPFLMDHLIHYSILVKNNYIGISSPKNDLIRVFNNIELENTFSFLLYHYHPQYYHDRMSGKYFWYNASSEQGYLNKINSHNTEIKGLVMNCRYTQGNHQLVLQFHDYLHYIGHSLPFPVVIYLLSNQFSSEKKKFMSNSHHFHNYFHHSLYTSTLIVWSCVRSLLLSQESEWELLLLQYMEIIKSNKRNNQLVLTGLLDMALKSTRFSQILCIYTNNPNSPIMNIFQKSLFKECDFLLTCKSMKSSEENIERNEDQNMNGKYEKRNSSEIHGKGVINRLRTVQDSMEGLNLRMSSVSSLINKCFDTISETSENLNRSSLNILQFENKKHSLANVQFSFFYILCQLGEMAKYRNRKEGGLGLPIEEDDNPSALIGRLNSKEIAQLKSEIAQDLLAKIENVIQRKEYKNVPFLNTNMLKSSENKTKLLSIKKINKLKILQSAKNIPYLLSLQLTDHNSDNQDTLVDISKIEPEQDYEMTINLIVKCNDDCRQDVITMQYIHVFQKIFELYNIPVWLYPYRILPMMFKDINNSVIYGGIIEFIEDSISLHEIHELHSEGGLKAYYESTFGGKNSHIKKLENDNNVSYEQARYNFISSLAGYSIACYVLQIKDRHNGNILITKNGHIIHIDYGFIFDISPGNNLHFERAAFKVTQEMLDFMDDQVDLFDDLCLSGFLAVREHADLLLSLTQMLINSGIPCFRGETIKKLKERLLLNFSQQQASNIFSKKIHSAHNHITTKGYDLVQFIQQGIK
 
Inhibitor
Name:
BDBM533837
Synonyms:
Methyl 2-chloro-5-(N-methyl-3-(3-methyl-4-(carbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamido)benzoate (1.22) | WO2022079616, Example 1.22
Type:
Small organic molecule
Emp. Form.:
C26H23ClN4O4
Mol. Mass.:
490.938
SMILES:
CNC(=O)c1ccc(cc1C)-c1cnn2ccc(cc12)C(=O)N(C)c1ccc(Cl)c(c1)C(=O)OC
Structure:
Search PDB for entries with ligand similarity: