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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM535402
Substrate
n/a
Meas. Tech.
Binding Assay (ELISA)
IC50
0.930±n/a nM
Citation
 Chessari, G; Lyons, JF Combination of isoindolinone derivatives with SGI-110 US Patent  US11236047 Publication Date 2/1/2022 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM535402
Synonyms:
(3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-4-fluoro-6- {1-hydroxy-1-[1-(1,3-oxazole-2- carbonyl)piperidin-4-yl]ethyl}-3- methoxy-2,3-dihydro-1H-isoindol-1- one Ex. 295 is the slower eluting isomer | US11236047, Example 295 | US20230338337, Compound 295
Type:
Small organic molecule
Emp. Form.:
C32H29Cl2FN4O5
Mol. Mass.:
639.501
SMILES:
CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(cc(F)c12)C(C)(O)C1CCN(CC1)C(=O)c1ncco1)c1ccc(Cl)cc1 |r|
Structure:
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