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Target
OTU domain-containing protein 7B
Ligand
BDBM443347
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
550±n/a nM
Citation
 Kemp, MI; Stockley, ML; Woodrow, MD; Jones, A Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors US Patent  US11236092 Publication Date 2/1/2022 
Target
Name:
OTU domain-containing protein 7B
Synonyms:
Cellular zinc finger anti-NF-kappa-B protein | Cezanne | OTU7B_HUMAN | OTUD7B | ZA20D1 | Zinc finger A20 domain-containing protein 1 | Zinc finger protein Cezanne
Type:
Protein
Mol. Mass.:
92527.32
Organism:
Human
Description:
Q6GQQ9
Residue:
843
Sequence:
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF
  
Inhibitor
Name:
BDBM443347
Synonyms:
6'-(4-(Morpholine-4-carbonyl)phenyl)- 2'-oxo-1',4'-dihydro-2'H- spiro[pyrrolidine-3,3'-quinoline]-1- carbonitrile | US10654853, Example 120 | US11236092, Example 120
Type:
Small organic molecule
Emp. Form.:
C24H24N4O3
Mol. Mass.:
416.4724
SMILES:
O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2NC(=O)C3(CCN(C3)C#N)Cc2c1
Structure:
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