Reaction Details Report a problem with these data
Target
Flap endonuclease 1
Ligand
BDBM538181
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
19.2±n/a nM
Citation
 Gahman, T; Shiau, A; Kolodner, R 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators US Patent  US11253521 Publication Date 2/22/2022 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM538181
Synonyms:
US11253521, No. 51
Type:
Small organic molecule
Emp. Form.:
C15H11FN2O5S
Mol. Mass.:
350.322
SMILES:
Cc1cccc(c1)S(=O)(=O)c1c(F)ccc2c1[nH]c(=O)n(O)c2=O
Structure:
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