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Target
GTPase NRas
Ligand
BDBM538626
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
9350±n/a nM
Citation
 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors US Patent  US11254667 Publication Date 2/22/2022 
Target
Name:
GTPase NRas
Synonyms:
HRAS1 | NRAS | RASN_HUMAN | Transforming protein N-Ras
Type:
PROTEIN
Mol. Mass.:
21223.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_839699
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
  
Inhibitor
Name:
BDBM538626
Synonyms:
NCGC 00371485 | US11254667, Compound I-29
Type:
Small organic molecule
Emp. Form.:
C21H23N7O
Mol. Mass.:
389.4536
SMILES:
COc1cc2ncc(-c3cccc(NC4CCCNC4)n3)n2cc1-c1cn[nH]c1
Structure:
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