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Target
Nuclear factor erythroid 2-related factor 2
Ligand
BDBM304963
Substrate
n/a
Meas. Tech.
BEAS-2B NQO1 MTT Assay
EC50
55000±n/a nM
Citation
 Davies, TG; Woolford, AJ; Willems, HM; Norton, D; Heightman, TD; Kerns, JK Nrf2 regulators US Patent  US10144731 Publication Date 12/4/2018 
Target
Name:
Nuclear factor erythroid 2-related factor 2
Synonyms:
HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2
Type:
PROTEIN
Mol. Mass.:
67786.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107924
Residue:
605
Sequence:
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
  
Inhibitor
Name:
BDBM304963
Synonyms:
2-{34-Methyl-3,3-dioxo-10-oxa-3λ6-thia-2,17,18,19-tetraazaheptacyclo[24.5.2.12,11.120,24.04,9.017,21.029,32]pentatriaconta-4(9), 5,7,14,18,20(34),21,23,26(33),27,29(32)-undecaen-25-yl}acetic acid | US10144731, Example 267
Type:
Small organic molecule
Emp. Form.:
C32H32N4O5S
Mol. Mass.:
584.685
SMILES:
Cc1c2ccc3n(CC=CCCC4CN(C5CCc6ccc(cc56)C2CC(O)=O)S(=O)(=O)c2ccccc2O4)nnc13 |w:9.9|
Structure:
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