Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E-binding protein 1
Ligand
BDBM545473
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
3.32±n/a nM
Citation
 Sperry, S; Xiang, AX; Ernst, JT; Reich, SH; Sprengeler, PA; Shaghafi, M; Michels, T; Nilewski, C; Tran, CV; Packard, GK; Grubbs, A; Urkalan, K; Mukaiyama, T EIF4E-inhibiting compounds and methods US Patent  US11286268 Publication Date 3/29/2022 
Target
Name:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:
4EBP1_HUMAN | EIF4EBP1 | GFP-4EBP | GFP-4EBP1 | Green fluorescent protein-Eukaryotic initiation factor 4E (eIF4E) binding protein
Type:
Fusion protein
Mol. Mass.:
12578.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
118
Sequence:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
  
Inhibitor
Name:
BDBM545473
Synonyms:
US11286268, Compound 964
Type:
Small organic molecule
Emp. Form.:
C33H21ClF4N6O4S
Mol. Mass.:
709.069
SMILES:
Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4nc(C)ncc4F)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1 |(10,2.69,;8.67,1.93,;7.34,2.7,;6,1.93,;4.67,2.69,;4.67,4.23,;3.33,5,;3.33,6.54,;2,4.23,;2,2.69,;3.33,1.93,;3.33,.38,;2,-.38,;2,-1.93,;.67,-2.69,;.67,-4.23,;2,-5,;-.67,-5,;-2,-4.23,;-3.33,-5,;-4.67,-4.23,;-4.67,-2.69,;-6,-1.93,;-7.34,-2.69,;-8.67,-1.93,;-10,-2.69,;-8.67,-.38,;-7.34,.38,;-6,-.38,;-4.67,.38,;-3.33,-1.93,;-3.33,-.38,;-3.33,1.15,;-2,-2.69,;-.67,-1.93,;-.67,-.38,;-6,-5,;-7.34,-5.78,;-6,-6.54,;-7.34,-4.23,;6,.38,;4.86,-.65,;5.48,-2.05,;7.02,-1.89,;8.05,-3.04,;7.57,-4.5,;9.55,-2.72,;7.34,-.38,;8.67,.38,)|
Structure:
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