Reaction Details Report a problem with these data
Target
Polymerase basic protein 2
Ligand
BDBM552164
Substrate
n/a
Meas. Tech.
EN PA FRET Inhibition Assay
IC50
6.00±n/a nM
Citation
 Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent  US11312727 Publication Date 4/26/2022 
Target
Name:
Polymerase basic protein 2
Synonyms:
B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3
Type:
Protein
Mol. Mass.:
85824.43
Organism:
Influenza A virus (strain A/WS/1933 H1N1)
Description:
B4URF7
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRISKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM552164
Synonyms:
(*Z)-4-hydroxy-15-phenyl-8,15-dihydro-7H-6,16-methanobenzo[j]pyrido[1,2-b][1,2,5]triazacyclododecine-3,5-dione | US11312727, Compound 54B
Type:
Small organic molecule
Emp. Form.:
C25H23N3O3
Mol. Mass.:
413.4684
SMILES:
Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccccc4\C=C/CCC3)n2ccc1=O |r,c:23|
Structure:
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