Reaction Details Report a problem with these data
Target
GTP-binding protein Rheb
Ligand
BDBM554571
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<10000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554571
Synonyms:
US11339144, Compound I-24
Type:
Small organic molecule
Emp. Form.:
C26H29BrN2O3S
Mol. Mass.:
529.489
SMILES:
CN(C)C(=O)c1ccc(Cn2c(cc3c(Br)cc(SCC4CCCCC4)cc23)C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: