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Target
GTP-binding protein Rheb
Ligand
BDBM554579
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<10000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Human
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554579
Synonyms:
US11339144, Compound I-32
Type:
Small organic molecule
Emp. Form.:
C27H23Cl4FN4OS
Mol. Mass.:
612.373
SMILES:
CN1CCCN(CC1)c1ccc(NC(=O)c2cc3c(Sc4ccc(Cl)cc4Cl)cc(Cl)c(Cl)c3[nH]2)cc1F
Structure:
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