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Target
GTP-binding protein Rheb
Ligand
BDBM554596
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<10000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554596
Synonyms:
US11339144, Compound I-49
Type:
Small organic molecule
Emp. Form.:
C15H8Cl3NO2
Mol. Mass.:
340.589
SMILES:
OC(=O)c1cc2c(cc(Cl)cc2[nH]1)-c1cc(Cl)cc(Cl)c1
Structure:
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