Reaction Details Report a problem with these data
Target
GTP-binding protein Rheb
Ligand
BDBM554568
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<10000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Human
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554568
Synonyms:
US11339144, Compound I-21 | US11339144, Compound I-51
Type:
Small organic molecule
Emp. Form.:
C19H15Cl4N3OS
Mol. Mass.:
475.219
SMILES:
CN1CC(C1)NC(=O)c1cc2c(Sc3ccc(Cl)cc3Cl)cc(Cl)c(Cl)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: