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Target
GTP-binding protein Rheb
Ligand
BDBM554622
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<10000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Human
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554622
Synonyms:
US11339144, Compound I-75
Type:
Small organic molecule
Emp. Form.:
C25H19Cl3N2O3S
Mol. Mass.:
533.854
SMILES:
CN(C)C(=O)c1ccc(Cn2c(cc3c(Cl)cc(Sc4ccc(Cl)c(Cl)c4)cc23)C(O)=O)cc1
Structure:
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