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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM107700
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
52300±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  US11426393 Publication Date 8/30/2022 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM107700
Synonyms:
US11426393, Compound Table XV.6 | US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2- carbonyl)-amino]-acetic acid methyl ester | US9598370, Example 00131 | USRE47437, Example [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2-carbonyl)-amino]-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C16H16N2O4
Mol. Mass.:
300.3092
SMILES:
COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Structure:
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