Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM571881
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.073±n/a nM
Citation
 Ichihashi, Y; Inagaki, M; Masuda, K Cyclic compound having dopamine D3 receptor antagonistic effect US Patent  US11447484 Publication Date 9/20/2022 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM571881
Synonyms:
US11447484, Compound I-038
Type:
Small organic molecule
Emp. Form.:
C26H34F2N4O3
Mol. Mass.:
488.57
SMILES:
CCn1c(cccc1=O)C(=O)N[C@H]1CC[C@H](CCN2C[C@@H]3C[C@@]3(C2)c2cc(on2)C(C)(F)F)CC1 |r,wU:15.16,22.26,wD:12.12,20.21,(5.56,5.55,;5.56,4.01,;6.89,3.24,;6.89,1.7,;8.22,.93,;9.56,1.7,;9.56,3.24,;8.22,4.01,;8.22,5.55,;5.56,.93,;5.56,-.61,;4.22,1.7,;2.89,.93,;1.56,1.7,;.22,.93,;.22,-.61,;-1.11,-1.38,;-1.11,-2.92,;-2.45,-3.69,;-2.61,-5.23,;-4.11,-5.55,;-5.65,-5.55,;-4.88,-4.21,;-3.85,-3.07,;-6.13,-3.31,;-6.13,-1.77,;-7.59,-1.29,;-8.5,-2.54,;-7.59,-3.78,;-8.07,.17,;-9.56,.57,;-6.57,.75,;-7.67,1.66,;1.56,-1.38,;2.89,-.61,)|
Structure:
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