Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Ligand
BDBM576248
Substrate
n/a
Meas. Tech.
Probe Displacement Assay
IC50
2.00±n/a nM
Citation
 Tami, M; Dale, R; Brock, S; Jocelyn, W INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS WIPO WO2022109580 Publication Date -1/27/2022 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Synonyms:
TYK2 | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
35197.67
Organism:
Human
Description:
P29597[556-871]
Residue:
316
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQP
  
Inhibitor
Name:
BDBM576248
Synonyms:
WO2022109580, Example 9
Type:
Small organic molecule
Emp. Form.:
C21H26N6O5
Mol. Mass.:
442.4683
SMILES:
COCCOc1cc(nc(c1)[C@@]1(CCOC1)OC)-n1nc(C)c2cnc(NC(N)=O)cc12 |r|
Structure:
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