Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO [473-894,Q764R]
Ligand
BDBM588222
Substrate
n/a
Meas. Tech.
AXL Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Tso, K; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11542259 Publication Date 1/3/2023 
Target
Name:
Tyrosine-protein kinase receptor UFO [473-894,Q764R]
Synonyms:
AXL | Tyrosine-protein kinase receptor UFO (473-894)(Q764R) | UFO | UFO_HUMAN
Type:
n/a
Mol. Mass.:
47245.78
Organism:
Homo sapiens (Human)
Description:
P30530[473-894,Q764R]
Residue:
422
Sequence:
HRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRRGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM588222
Synonyms:
1-N'-(4-fluorophenyl)-1-N- [4-[7-methoxy-6- [[(2R)-pyrrolidin-2- yl]methylcarbamoyl]quinolin- 4-yl]oxyphenyl]cyclopropane- 1,1-dicarboxamide | US11542259, Compound 21
Type:
Small organic molecule
Emp. Form.:
C33H32FN5O5
Mol. Mass.:
597.6361
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1C(=O)NC[C@H]1CCCN1 |r|
Structure:
Search PDB for entries with ligand similarity: