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Target
GTPase NRas
Ligand
BDBM538642
Substrate
n/a
Meas. Tech.
IC50 Kinase Assays
IC50
1760±n/a nM
Citation
 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors US Patent  US11542261 Publication Date 1/3/2023 
Target
Name:
GTPase NRas
Synonyms:
HRAS1 | NRAS | RASN_HUMAN | Transforming protein N-Ras
Type:
PROTEIN
Mol. Mass.:
21223.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_839699
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
  
Inhibitor
Name:
BDBM538642
Synonyms:
NCGC 00249372 | US11254667, Compound I-16 | US11542261, Compound I-16
Type:
Small organic molecule
Emp. Form.:
C16H16ClN5
Mol. Mass.:
313.785
SMILES:
Clc1ccc2ncc(-c3cccc(NC4CCNC4)n3)n2c1
Structure:
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