Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM593734
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.063±n/a nM
Citation
 Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent  US11578084 Publication Date 2/14/2023 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM593734
Synonyms:
US11578084, Compound I-017
Type:
Small organic molecule
Emp. Form.:
C26H36F3N5O2
Mol. Mass.:
507.5915
SMILES:
Cn1cc(CC(=O)N[C@H]2CC[C@](F)(CCN3CCc4ccc(OCC(C)(F)F)nc4CC3)CC2)cn1 |r,wU:11.12,wD:8.7,11.11,(13.36,1.84,;11.82,1.84,;10.91,3.09,;9.45,2.61,;8.11,3.38,;6.78,2.61,;6.78,1.07,;5.45,3.38,;4.11,2.61,;2.78,3.38,;1.44,2.61,;1.44,1.07,;1.44,-.47,;.11,.3,;-1.22,1.07,;-2.56,.3,;-2.44,-1.23,;-3.57,-2.28,;-5.09,-2.05,;-5.86,-3.38,;-7.4,-3.38,;-8.17,-2.05,;-9.71,-2.05,;-10.48,-.72,;-12.02,-.72,;-12.79,.62,;-12.02,-2.26,;-13.36,-1.49,;-7.4,-.72,;-5.86,-.72,;-5.3,.72,;-3.83,1.17,;2.78,.3,;4.11,1.07,;9.45,1.07,;10.91,.6,)|
Structure:
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