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Target
NAD(+) hydrolase SARM1 [50-724]
Ligand
BDBM600571
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
<1000±n/a nM
Citation
 Kolluri, R; Tegley, CM; Zhu, L; Brown, SP; Reynolds, CH; Tasker, AS; Grice, CA Substituted pyridine derivatives as SARM1 inhibitors US Patent  US11629136 Publication Date 4/18/2023 
Target
Name:
NAD(+) hydrolase SARM1 [50-724]
Synonyms:
KIAA0524 | NAD(+) hydrolase SARM1 (50-724) | SAMD2 | SARM | SARM1 | SARM1_HUMAN
Type:
Protein
Mol. Mass.:
74398.52
Organism:
Homo sapiens (Human)
Description:
aa 50-724
Residue:
675
Sequence:
PREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
  
Inhibitor
Name:
BDBM600571
Synonyms:
(S)-2,2,2-Trifluoro-1-(4-(pyridin-4-ylmethyl)-1H-imidazol-2-yl)ethan-1-amine and (R)-2,2,2-Trifluoro-1-(4-(pyridin-4-ylmethyl)-1H-imidazol-2-yl)ethan-1-amine | US11629136, Example 15a
Type:
Small organic molecule
Emp. Form.:
C11H11F3N4
Mol. Mass.:
256.227
SMILES:
N[C@@H](c1nc(Cc2ccncc2)c[nH]1)C(F)(F)F |r|
Structure:
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