Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM601478
Substrate
n/a
Meas. Tech.
Plaque Reduction Assay
EC50
28.0±n/a nM
Citation
 Cockerill, GS; Good, J; Cochrane, EJ Pharmaceutical compounds US Patent  US11634425 Publication Date 4/25/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM601478
Synonyms:
N-[(3S)-9-fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(2-fluorophenyl)imidazo[1,2-b]pyridazine-3-carboxamide | US11634425, Example 18
Type:
Small organic molecule
Emp. Form.:
C28H18F2N6O2
Mol. Mass.:
508.4783
SMILES:
Fc1cccc2c1NC(=O)[C@@H](NC(=O)c1c(nc3cccnn13)-c1ccccc1F)N=C2c1ccccc1 |c:34|
Structure:
Search PDB for entries with ligand similarity: