Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM601503
Substrate
n/a
Meas. Tech.
Plaque Reduction Assay
EC50
39.0±n/a nM
Citation
 Cockerill, GS; Good, J; Cochrane, EJ Pharmaceutical compounds US Patent  US11634425 Publication Date 4/25/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM601503
Synonyms:
2-(2- Fluorophenyl)-7- methyl-N-[(3S)- 2-oxo-5-phenyl- 1,3-dihydro-1,4- benzodiazepin-3- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide | US11634425, Example 37
Type:
Small organic molecule
Emp. Form.:
C29H21FN6O2
Mol. Mass.:
504.5144
SMILES:
Cc1ccnc2c(C(=O)N[C@H]3N=C(c4ccccc4)c4ccccc4NC3=O)c(nn12)-c1ccccc1F |t:11|
Structure:
Search PDB for entries with ligand similarity: