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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-321]
Ligand
BDBM50218196
Substrate
n/a
Meas. Tech.
Metabolic Measurements
Ki
2500±n/a nM
Citation
 Tonks, N; Krishnan, N Treatment of Rett syndrome US Patent  US11660306 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-321]
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B)
Type:
Enzyme
Mol. Mass.:
37311.71
Organism:
Homo sapiens (Human)
Description:
P18031 (1-321 aa)
Residue:
321
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHN
  
Inhibitor
Name:
BDBM50218196
Synonyms:
3-beta,28-Dihydroxy-urs-12-ene | CHEMBL399873 | US11660306, Example Uveol | Uvaol | urs-12-ene-3beta,28-diol
Type:
Small organic molecule
Emp. Form.:
C30H50O2
Mol. Mass.:
442.7168
SMILES:
C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C |r,c:11|
Structure:
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