Reaction Details Report a problem with these data
Target
Granzyme B
Ligand
BDBM605067
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
>5000±n/a nM
Citation
 Bilcer, GM; Kelly, TA Granzyme B directed imaging and therapy US Patent  US11667645 Publication Date 6/6/2023 
Target
Name:
Granzyme B
Synonyms:
CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB
Type:
PROTEIN
Mol. Mass.:
27735.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_469245
Residue:
247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
  
Inhibitor
Name:
BDBM605067
Synonyms:
(2S,5S)-5-[(S)-2-(2-Benzo[b]thiophen-3- yl-acetylamino)-3-(4-hydroxy-phenyl)- propionylamino]-4-oxo-1,2,4,5,6,7- hexahydro-azepino[3,2,1-hi]indole-2- carboxylic acid (1H-[1,2,3]triazol-4- ylmethyl)-amide | US11667645, Compound C010
Type:
Small organic molecule
Emp. Form.:
C35H33N7O5S
Mol. Mass.:
663.745
SMILES:
Oc1ccc(C[C@H](NC(=O)Cc2csc3ccccc23)C(=O)N[C@H]2CCc3cccc4C[C@H](N(c34)C2=O)C(=O)NCc2c[nH]nn2)cc1 |r|
Structure:
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