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Target
Tyrosine-protein kinase JAK2 [Y1007F,Y1008F]
Ligand
BDBM608028
Substrate
n/a
Meas. Tech.
JAK2 Binding Assay
Kd
<10±n/a nM
Citation
 Masse, CE; Greenwood, JR; Mondal, S; Xu, J; Ghanakota, P; McRobb, FM; Boyles, N 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors US Patent  US11691963 Publication Date 7/4/2023 
Target
Name:
Tyrosine-protein kinase JAK2 [Y1007F,Y1008F]
Synonyms:
Tyrosine-protein kinase JAK2 (Y1007F, Y1008F)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
130652.68
Organism:
Homo sapiens (Human)
Description:
O60674[Y1007F,Y1008F]
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEFFKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM608028
Synonyms:
US11691963, Example I-181
Type:
Small organic molecule
Emp. Form.:
C30H38ClN9O3
Mol. Mass.:
608.134
SMILES:
COCCN1CC[C@@H](C1)n1nc(Nc2nc3ncc(Oc4ccnc(NC(=O)C5CC5)c4)c(Cl)c3n2C)cc1C(C)(C)C |r|
Structure:
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