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Target
Histone-arginine methyltransferase CARM1
Ligand
BDBM440550
Substrate
n/a
Meas. Tech.
CARM1 Enzyme Assay
IC50
<100±n/a nM
Citation
 Chesworth, R; Moradei, OM; Shapiro, G; Jin, L; Babine, RE CARM1 INHIBITORS AND USES THEREOF US Patent  US20230279020 Publication Date 9/7/2023 
Target
Name:
Histone-arginine methyltransferase CARM1
Synonyms:
CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4)
Type:
Protein
Mol. Mass.:
65855.47
Organism:
Homo sapiens (Human)
Description:
Q86X55
Residue:
608
Sequence:
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIPTNTMHYGS
  
Inhibitor
Name:
BDBM440550
Synonyms:
US10633389, Example 216-3 | US20230279020, Example 216-3
Type:
Small organic molecule
Emp. Form.:
C24H29Cl2N5O4
Mol. Mass.:
522.424
SMILES:
CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2C[C@H](C2)OC)c(Cl)c(n1)-c1c(C)noc1C |r,wU:18.18,20.23,wD:3.3,(-10.28,2.34,;-8.95,1.57,;-7.61,2.34,;-6.28,1.57,;-6.28,.03,;-4.94,2.34,;-3.61,1.57,;-2.28,2.34,;-2.28,3.88,;-.94,4.65,;.39,3.88,;1.72,4.65,;.39,2.34,;-.94,1.57,;1.72,1.57,;3.06,2.34,;4.39,1.57,;5.73,2.34,;7.06,1.57,;8.55,1.97,;8.95,.48,;7.46,.08,;10.28,-.29,;10.28,-1.83,;4.39,.03,;5.73,-.74,;3.06,-.74,;1.72,.03,;3.06,-2.28,;1.81,-3.19,;.32,-2.79,;2.29,-4.65,;3.83,-4.65,;4.3,-3.19,;5.79,-2.79,)|
Structure:
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