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Target
Monoglyceride lipase
Ligand
BDBM617015
Substrate
n/a
Meas. Tech.
MAGL Enzyme Inhibition Assay
IC50
3530±1320 nM
Citation
 Omran, Z Disulfiram derivatives as ALDH1A1 and MAGL inhibitors US Patent  US11753371 Publication Date 9/12/2023 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM617015
Synonyms:
US11753371, Compound II-2g
Type:
Small organic molecule
Emp. Form.:
C16H28N2O4S4
Mol. Mass.:
440.665
SMILES:
CCOC(=O)CCN(CC)C(=S)SSC(=S)N(CC)CCC(=O)OCC
Structure:
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