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Target
Interleukin-17F
Ligand
BDBM617670
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
126±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617670
Synonyms:
US20230286943, Example 138
Type:
Small organic molecule
Emp. Form.:
C24H28F3N7O2
Mol. Mass.:
503.52
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cn1)-c1c(cnn1C)C(F)(F)F |r,wU:1.0,wD:7.8,4.3,(2,6.65,;2,5.11,;3.33,4.34,;3.33,2.8,;2,2.03,;.67,2.8,;.67,4.34,;2,.49,;3.33,-.28,;4.67,.49,;4.67,2.03,;6,-.28,;7.41,.35,;8.44,-.79,;7.67,-2.13,;6.16,-1.81,;5.02,-2.84,;.67,-.28,;.67,-1.82,;-.67,.49,;-2,-.28,;-2,-1.82,;-3.33,-2.59,;-4.67,-1.82,;-4.67,-.28,;-3.33,.49,;-6,-2.59,;-6.16,-4.12,;-7.67,-4.44,;-8.44,-3.1,;-7.41,-1.96,;-7.73,-.45,;-5.02,-5.15,;-5.34,-6.65,;-3.55,-4.67,;-3.87,-6.18,)|
Structure:
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