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Target
NAD(+) hydrolase SARM1
Ligand
BDBM618465
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Bentley, J; Parrott, SA; Brearley, AS; Bosanac, T; Hughes, RO; Devraj, R INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1 US Patent  US20230286978 Publication Date 9/14/2023 
Target
Name:
NAD(+) hydrolase SARM1
Synonyms:
3.2.2.- | 3.2.2.6 | HsTIR | KIAA0524 | MyD88-5 | NAD(+) hydrolase SARM1 | NADP(+) hydrolase SARM1 | NADase SARM1 | SAM domain-containing protein 2 | SAMD2 | SAMD2 GN | SARM | SARM1 | SARM1_HUMAN | Sterile alpha and Armadillo repeat protein | Sterile alpha and TIR motif-containing protein 1 | Sterile alpha motif domain-containing protein 2 | Synonyms=KIAA0524 | Tir-1 homolog | hSARM1
Type:
PROTEIN
Mol. Mass.:
79387.31
Organism:
Human
Description:
ChEMBL_119100
Residue:
724
Sequence:
MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
  
Inhibitor
Name:
BDBM618465
Synonyms:
US20230286978, Example 1
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4O
Mol. Mass.:
362.812
SMILES:
Clc1ccc(CNC(=O)c2cccc3c(n[nH]c23)-c2ccncc2)cc1
Structure:
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