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Target
Cyclin-dependent kinase 6
Ligand
BDBM621028
Substrate
n/a
Meas. Tech.
CDK6 Kinase Activity Analysis and Detection Method
IC50
175±n/a nM
Citation
 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF US Patent  US20230303553 Publication Date 9/28/2023 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM621028
Synonyms:
4-(benzothiazole-6-yl)-5-fluoro-N-(5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)pyrimidine-2-amine | US20230303553, Example 11
Type:
Small organic molecule
Emp. Form.:
C24H26FN7S
Mol. Mass.:
463.574
SMILES:
CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1
Structure:
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