Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9 [133-239]
Ligand
BDBM621711
Substrate
n/a
Meas. Tech.
BRD9 Bromodomain TR-FRET Competition Binding Assay
IC50
<10±n/a nM
Citation
 Zhou, Q; Bocker, M; Millan, DS; Chan, HM; Soares, L; Netherton, MR; Ruppel, SK; Yang, Z; Lowe, JT; Brucelle, F Methods and compounds for treating disorders US Patent  US11773085 Publication Date 10/3/2023 
Target
Name:
Bromodomain-containing protein 9 [133-239]
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)(133-239)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12383.34
Organism:
Homo sapiens (Human)
Description:
aa 133-239
Residue:
107
Sequence:
PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM621711
Synonyms:
(2S,4R)-1-[(2S)-2-[10-[2-([[2,6-dimethoxy-4-(2-methyl-1-oxo-2,7-naphthyridin-4-yl)phenyl]methyl](methyl)amino)acetamido]decanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | US11773085, Compound D18
Type:
Small organic molecule
Emp. Form.:
C53H70N8O8S
Mol. Mass.:
979.237
SMILES:
COc1cc(cc(OC)c1CN(C)CC(=O)NCCCCCCCCCC(=O)N[C@@H](C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C)-c1cn(C)c(=O)c2cnccc12 |r|
Structure:
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