Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM629259
Substrate
n/a
Meas. Tech.
CSNK1A1 Inhibitory activity Assay 2
IC50
1.66±n/a nM
Citation
Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, null; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; Berger, M; Rupaimoole, R; Lienau, P; Orsi, D; McKinney, D; Brezezinka, K SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF US Patent US20230339939 Publication Date 10/26/2023
More Info.:
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
Inhibitor
Name:
BDBM629259
Synonyms:
2-(4-fluorophenyl)-N-{4-[7-(pyridin-2-yl)-5H-pyrrolo[3,2-c]pyridazin-6-yl]pyridin-2-yl}acetamide | US20230339939, Example 21
Type:
Small organic molecule
Emp. Form.:
C24H17FN6O
Mol. Mass.:
424.4298
SMILES:
Fc1ccc(CC(=O)Nc2cc(ccn2)-c2[nH]c3ccnnc3c2-c2ccccn2)cc1