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Target
Casein kinase I isoform delta
Ligand
BDBM629259
Substrate
n/a
Meas. Tech.
CSNK1D-Inhibitory Activity Assay
IC50
3.96±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, null; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; Berger, M; Rupaimoole, R; Lienau, P; Orsi, D; McKinney, D; Brezezinka, K SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF US Patent  US20230339939 Publication Date 10/26/2023 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Human
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM629259
Synonyms:
2-(4-fluorophenyl)-N-{4-[7-(pyridin-2-yl)-5H-pyrrolo[3,2-c]pyridazin-6-yl]pyridin-2-yl}acetamide | US20230339939, Example 21
Type:
Small organic molecule
Emp. Form.:
C24H17FN6O
Mol. Mass.:
424.4298
SMILES:
Fc1ccc(CC(=O)Nc2cc(ccn2)-c2[nH]c3ccnnc3c2-c2ccccn2)cc1
Structure:
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