Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM629277
Substrate
n/a
Meas. Tech.
CSNK1A1 Inhibitory activity Assay 2
IC50
3.49±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, null; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; Berger, M; Rupaimoole, R; Lienau, P; Orsi, D; McKinney, D; Brezezinka, K SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF US Patent  US20230339939 Publication Date 10/26/2023 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Human
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM629277
Synonyms:
2-(4-fluorophenyl)-N-(4-{7-[methyl(1-methylpiperidin-4-yl)amino]-3-(pyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl}pyridin-2-yl)acetamide | US20230339939, Example 39
Type:
Small organic molecule
Emp. Form.:
C32H32FN7O
Mol. Mass.:
549.6412
SMILES:
CN(C1CCN(C)CC1)c1ccnc2c(c([nH]c12)-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccccn1
Structure:
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