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Target
Cell division cycle 7-related protein kinase
Ligand
BDBM636604
Substrate
n/a
Meas. Tech.
CDC7 Kinase Biochemical Assay
IC50
<1±n/a nM
Citation
 HUANG, X; MONDAL, S; GHANAKOTA, P; BOYLES, N; FRYE, L; LEVINSON, A; GREENWOOD, JR; BOS, P; BHAT, S; GERASYUTO, A; TANG, H HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER US Patent  US20230365584 Publication Date 11/16/2023 
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Inhibitor
Name:
BDBM636604
Synonyms:
7-[(3,3-difluoropyrrolidin-1- yl)methyl]-2-(1H-pyrazol-4-yl)-12- oxa-3-thia-6-azatricyclo [6.4.1.04,13]trideca-1,4(13),7- trien-5-one | US20230365584, Compound 25. | US20230365584, Compound 42.
Type:
Small organic molecule
Emp. Form.:
C18H18F2N4O2S
Mol. Mass.:
392.423
SMILES:
FC1(F)CCN(Cc2[nH]c(=O)c3sc(-c4cn[nH]c4)c4OCCCc2c34)C1
Structure:
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