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Target
Arginase-1
Ligand
BDBM642225
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
29.0±n/a nM
Citation
 Kurhade, S; Dömling, A Arginase inhibitors US Patent  US11845767 Publication Date 12/19/2023 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM642225
Synonyms:
(5-amino-5-(1-(2-((3,4- dimethoxyphenethyl)amino)-2-oxoethyl)- 1H-tetrazol-5-yl)pentyl)boronic acid | US11845767, Example 270
Type:
Small organic molecule
Emp. Form.:
C18H29BN6O5
Mol. Mass.:
420.271
SMILES:
COc1ccc(CCNC(=O)Cn2nnnc2C(N)CCCCB(O)O)cc1OC
Structure:
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